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人员

  • 简要介绍:陈靖祺,复旦大学类脑智能科学与技术研究院副研究员,博士生导师。复旦大学生物类本硕博学位,并在美国加州大学伯克利分校进行了短期联合培养(博士)、全职博士后研究。2019年初任复旦大学类脑智能科学与技术研究院青年副研究员,2022年12月起任副研究员。主要方向为大数据与可解释算法所驱动的脑疾病基因组机制解读,及这些新机制的转化医学前驱研究。已有20余篇研究成果发表于Genome Medicine, Nucleic Acids Research, Molecular Psychiatry, Briefings in Bioinformatics等业内高水平期刊。目前在研课题包括:(1)脑等复杂疾病罕见结构变异的鉴定、多模态功能预测算法;(2)基因组重复元件与脑疾病(计算实验结合);(3)单细胞水平上的脑疾病遗传调控图谱解析与表型预测。研究致力于设计开发具有生物学意义、有助于对接临床的生物信息学方法。可来信咨询研究生、博士后职位。
  • 代表成果:

    近三年

    1.Qiongjie Zhou#, Guiying Dong#, Qiaomei Wang, Haiping Shen, Yiping Zhang, Shikun Zhang,Jingqi Chen* and Xiaotian Li*. Preconception folic acid supplementation for the prevention of birth defects: a prospective, population‑based cohort study in mainland China.BMC Pregnancy Childbirth. DOI:10.1186/s12884-024-06283-8 (2024)

    2.Bo Yuan#, Shuqian Zhang#, Liting Song#, Jinlong Chen, Jixin Cao, Jiayi Qiu, Zilong Qiu,Jingqi Chen*, Xing-Ming Zhao*, and Tian-Lin Cheng*. Engineering of cytosine base editors with DNA damage minimization and editing scope diversification.Nucleic Acids Res.DOI:10.1093/nar/gkad855 (2023)

    3.J Chen*, L Song, A Yang, G Dong, and X-M Zhao*. Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders.Mol Psychiatry. doi: 10.1038/s41380-022-01529-3 (2022)

    4.L Song#,J Chen#,C-Y Lo,Q Guo,the ZIB Consortium, J Feng, and X-M Zhao*.Impaired type I interferon signaling activity implicated in the peripheral blood transcriptome of preclinical Alzheimer’s disease.eBioMedicine.DOI:10.1016/j. ebiom.2022.104175 (2022)

    5.G Dong, J Feng, F Sun,J Chen* and X-M Zhao*. A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank.Genome Med. doi: 10.1186/s13073-021-00927-6 (2021)

    6.X Zhao#,J Chen#, P Xiao, J Feng, Q Nie, and X-M Zhao. Identifying age-specific gene signatures of the human cerebral cortex with joint analysis of transcriptomes and functional connectomes.Brief Bioinform. doi: 10.1093/bib/bbaa388 (2021)

    7.J Chen, G Dong, L Song, X Zhao, J Cao, X Luo, J Feng*, and X-M Zhao*. Integration of Multimodal Data for Deciphering Brain Disorders.Annu Rev Biomed Data Sci. DOI: 10.1146/annurev-biodatasci-092820-020354 (2021)