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人员

  • 简要介绍:肖晓,青年研究员,博士生导师,复旦大学认知神经科学中心执行主任,复旦大学附属华山医院双聘研究员。上海市东方英才(2023),上海科技启明星(2019),上海市神经科学学会疼痛转化研究分会副主任,上海市民建科教委员会副主任,上海民建人工智能专委会副主任,中国生理学会青年委员会委员,民建复旦大学委员会委员,Behavioural Brain Research 杂志副主编。学术专长为使用神经生物学、认知心理学和计算科学等交叉学科的前沿技术,围绕“情感的中枢机制及可塑性调控”这一科学主题,系统研究了情绪记忆的神经生理机制,推动了情感障碍中枢机制研究的发展及临床诊疗应用,并建立了一系列行为心理治疗为基础的创新技术。在神经生物学权威期刊:Advanced Science, Cell Reports(3篇),Journal of Neuroscience(2篇),Neuroscience Biobehavioral Reviews,Research,Pain,Anesthesiology等共发表论文30余篇,第一或通讯作者(含共同)22篇。研究成果被领域内顶尖期刊如Science,Nature等多次正面引用,并被临床神经病学教科书Handbook of Clinical Neurology和神经病理性疼痛测量教科书The Oxford Handbook of the Neurobiology of Pain引用与收录。主持及参与2030脑科学计划、科技部重点研发计划、国家自然科学基金面上和青年项目、东方英才项目(原上海市青年拔尖人才)、上海市科技启明星计划等;获批专利6项;著有中文科普著作《探索脑的奥秘》,翻译英文译著4本,其中神经外科医生Oliver Sacks著作《最初的爱,最后的故事》,获豆瓣网“科学·新知”年度榜单Top10推荐。
  • 代表成果:

    1. Intermittent vibration induces sleep via an allatostatin A-GABAsignaling pathway and ameliorates memory impairment in Alzheimer's disease models. Yang Mou, Yan Zhang, Yuxian Zheng, Guang He, Zhi-Xiang Xu, Xiao Xiao#, Yong Ping#, Advanced Science, (2024), https://doi.org/10.1002/advs.202411768

    2. Coordinated interactions between the hippocampus and retrosplenial cortex in spatial memory. Ruiqing Hou, Ziyue Liu, Zichen Jin, Dongxue Huang, Yue Hu, Wenjie Du, Danyi Zhu, Leiting Yang, Yuanfeng Weng, Tifei Yuan, Yingwei Wang, Bin Lu, Yong Ping#, Xiao Xiao#, Research, (2024), Volume 7, 0521

    3. Differential efficacy of modified enriched environment on motor, emotion, and cognition in cortical ischemic mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Yuanfeng Weng, Xiao Xiao#, Yi Wu#, Junfa Wu#, Cerebral Cortex, Volume 34, Issue 9, September 2024, bhae375, https://doi.org/10.1093/cercor/bhae375

    4. Impact of abl2/arg deficiency on anxiety and depressive behaviors in mice. Xiaojuan Yao, Ruiying Chen, Hongting Chen, Anthony Koleske, Xiao Xiao#, Behavioural Brain Research, (2024), Volume 468, 115022, https://doi.org/10.1016/j.bbr.2024.115022

    5. Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Qianfeng Wang, Ming Ding, Ruiqing Hou, Kewei Yu, Xiao Xiao#, Yi Wu#, Junfa Wu#, Experimental Neurology, (2024) Volume 377, 114801, https://doi.org/10.1016/j.expneurol.2024.114801

    6. 小鼠二选一赌博实验范式设计及验证。古玥琳,肖晓#,山东大学学报(医学版),(2024)第62卷,第三期

    7. High-frequency repetitive transcranial magnetic stimulation promotes ipsilesional functional hyperemia and motor recovery in mice with ischemic stroke. Li Liu*, Ming Ding*, Junfa Wu, Yuwen Zhang, Qianfeng Wang, Nianhong Wang, Lu Luo, Kewei Yu, Yunhui Fan, Jingjun Zhang, Yi Wu#, Xiao Xiao#, Qun Zhang#, Cerebral Cortex (2024) , 34 (3), bhae074

    8. Integrin α3 Is Required for High-Frequency Repetitive Transcranial Magnetic Stimulation–Induced Glutamatergic Synaptic Transmission in Mice with Ischemia. Li Liu*, Han Hu*, Junfa Wu*, Anthony J. Koleske, Hongting Chen, Nianhong Wang, Kewei Yu, Yi Wu#, Xiao Xiao#, Qun Zhang#, CNS Neuroscience & Therapeutics, (2023), 30 (4), e14498.

    9. Deep learning-based activity recognition and fine motor identification with 2D skeleton in cynomolgus monkeys. Chuxi Li*, Zifan Xiao*, Yerong Li, Zhinan Chen, Xun Ji, Yiqun Liu, Shufei Feng, Zhen Zhang, Kaiming Zhang, Jianfeng Feng, Trevor W. Robbins, Shisheng Xiong#, Yongchang Chen, Xiao Xiao#, Zoological Research, (2023) 44(5): 967-980. doi:10.24272/j.issn.2095-8137.2022.449

    10. Serpin family proteins as potential biomarkers and therapeutic drugs in stroke: A systematic review and meta-­analysis on clinical/preclinical studies. Bing Yan, Lu Luo, Li Liu, Zhenyu Wang, Ruiying Chen, Yi Wu, Xiao Xiao#, CNS Neuroscience & Therapeutics, (2023) 29(7): 1738–1749.

    11. Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats. Li Liu, Ming Ding, Junfa Wu, Yuwen Zhang, Shaoqian Guo, Nianhong Wang, Kewei Yu, Lu Luo, Qianfeng Wang, Yuanfeng Weng, Quan Zhang, Kai Qiu, Yi Wu#, Xiao Xiao#, Qun Zhang#, Frontiers in Neuroscience, (2023) DOI: 10.3389/fnins.2023.1129590

    12. 广义线性模型在神经电生理信号分析中的应用。 刘子悦; 肖晓#复旦学报(自然科学版), (2023), DOI:10.15943/j.cnki.fdxb-jns.20230318.001

    13. A tassel-type multilayer flexible neural probe prepared by laser direct writing. Zipeng Ye, Jing Qi, Yiling Ni, Zhiyong Wu, Xiao Xiao#, Shisheng Xiong#, Chip, (2022). 1 (3), 100024. DOI: 10.1016/j.chip.2022.100024 (Cover paper)

    14. The role of glia underlying acupuncture analgesia in animal pain models, a systematic review and meta-analysis. Bing Yan, Shengyu Tang, Yuqiu Zhang, Xiao Xiao#, Pain Medicine (2022). , 24 (1), 11-24; doi: 10.1093/pm/pnac115

    15. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. Lu Luo*, Meixi Liu*, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao#, Yi Wu#, Journal of Neuroinflammation (2022) 19:141

    16. MonkeyPosekit: Automated Markerless 2D Pose Estimation of Monkey, Chuxi Li, Chi Yang, Yerong Li, Shufei Feng, Zhen Zhang, Shisheng Xiong#, Xiao Xiao#, IEEE- China Automation Congress (CAC) (2021) 1280-1284

    17. 基于时移和片组注意力融合的双流行为识别网络. 肖子凡, 刘逸群, 李楚溪, 张力, 王守岩, 肖晓#计算机系统应用 Computer Systems & Applications, (2022) 31(1):204−211

    18. The role of the anterior cingulate cortex in translational pain research. Xiao Xiao#, Ming Ding, Yuqiu Zhang#, Neuroscience Bulletin (2021) 37(3), 405-422

    19. Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Kai-Kai Zang *, Xiao Xiao*,Li-Qiang Chen,Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, Yu-Qiu Zhang. Anesthesiology (2020) Jul;133(1):165-184;

    20. Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Sara M. Katrancha, Amy Zhao, Amanda Jeng, Juliana Shaw, Minsheng Zhu, Christopher Pittenger, Charles Greer, Xiao Xiao#, Anthony J. Koleske# Cell Reports. (2019) 26:2805-2817

    21. A new perspective on the anterior cingulate cortex and affective pain. Xiao Xiao, Yuqiu Zhang#. Neuroscience & Biobehavioral Reviews (2018) 90:200-211

    22. Noonan syndrome-associated SHP2 dephosphorylates GluN2B to regulate NMDA receptor function. Aaron D. Levy*, Xiao Xiao*, Suma Priya Sudarsana Devi, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske# Cell Reports (2018) 24 (6):1523-1535

    23. CNS neurons deposit Laminin α5 to stabilize synapses. Mitchell H. Omar, Maghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske#, Cell Reports (2017) 21(5): 1281-1292

    24. Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice. Xiao Xiao, Aaron D. Levy, Brian J. Rosenberg, Michael J. Higley, Anthony J. Koleske#, Journal of Neuroscience, (2016) 36 (25): 6778-6791

    25. SIP 30 Is Required for Neuropathic Pain-Evoked Aversion in Rats. Mei Han, Xiao Xiao, Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Neuroscience,(2014) 34(2): 346-355

    26. Estrogen in the anterior cingulate cortex contributes to pain-related aversion. Xiao Xiao, Yan Zhang, Yan Yang, Zhi-Qi Zhao, Yu-Qiu Zhang#, Cerebral Cortex (2012) 23(9): 2190-2203

    27. Estrogen facilitates spinal cord synaptic transmission via mambrane-bound estrogen receptors: implications for pain hypersensitivity. Yan Zhang, Xiao Xiao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Biological Chemistry,(2012) 287(40):33268-81

    28. 综述:一念放下,万般自在——我们能否训练自己去遗忘疼痛. 肖晓, 生理学报Acta Physiologica Sinica, June 25, 2011, 63(3): 293–295

    29. NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Ting-Ting Li*, Wen-Hua Ren*, Xiao Xiao*, Long-Zhen Cheng, Xue-Han Zhang, Zhi-Qi Zhao, Yu-Qiu Zhang#. Pain, (2009) 146, 183–193