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人员

  • 简要介绍:原致远,博士生导师。研究方向为基因组大语言模型、生成式及可解释人工智能方法,及在单细胞/空间组学中的应用。2022年6月于清华大学自动化系获博士学位,2022年9月加入复旦大学任独立PI。入选国家高层次人才特殊支持计划青年项目,上海市人才计划(青年东方英才、晨光学者、扬帆计划、明珠菁英人才、青年科技35人引领计划)及复旦大学卓学人才计划。学术成果以第一/通讯作者身份发表在 Nat. Methods(2021/2023/2024)、Nat. Commun.(2022/2024/2025)、Nat. Protoc.(2024)、Cell Genom.(2024)等期刊。部分成果被选为 Nat. Methods TOP 1% 热点论文、Nat. Methods/Nat. Commun./Cell Genom. 亮点论文。一作/通讯获中国生物信息学十大进展(2次)、世界人工智能大会青年优秀论文奖。主持国家自然科学基金面上、青年和上海市各级科研项目,骨干参与国家重点研发计划、上海市重点专项。担任 Genom. Proteom. Bioinf.(GPB)、J. Genet. Genom.(JGG)青年编委。担任方法学(Nat. Methods/Nat. Biotechnol./Nat. Mach. Intell./Nat. Comput. Sci.),生物学(Nat. Metab., Nat. Struct. Mol. Biol., Cell Genom., Cell Syst.)及综合性(Nat. Commun., Science Advances, Natl Sci Rev, Cell Rep.)等数十种权威期刊审稿人。
  • 代表成果:

    [1] Z Yuan*, Q Zhou*, L Cai*, et al., Y Chen#, X Zhang# & MQ Zhang#.

    SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment.

    Nature Methods 18, 1223–1232 (2021).


    [2] Z Yuan*#, W Pan*, X Zhao, F Zhao, X Li, Y Zhao, MQ Zhang# & J Yao#.

    SODB facilitates comprehensive exploration of spatial omics data.

    Nature Methods 20, 387–399 (2023).


    [3] Z Yuan*#, F Zhao, S Lin, Y Zhao, J Yao, Y Cui, XY Zhang, Y Zhao#.

    Benchmarking spatial clustering methods with spatially resolved transcriptomics data.

    Nature Methods (2024).


    [4] Z Yuan*#, Y Li*, M Shi, F Yang, J Gao, J Yao# & MQ Zhang#.

    SOTIP is a versatile method for microenvironment modeling with spatial omics data.

    Nature Communications 13, 7330 (2022).


    [5] Z Yuan*#.

    MENDER: Fast and scalable tissue structure identification in Spatial Omics Data.

    Nature Communications 15, 207 (2024).


    [6] S Lin, F Zhao, Z Wu, J Yao, Y Zhao# & Z Yuan#.

    Streamlining spatial omics data analysis with Pysodb.

    Nature Protocols (2024).


    [7] S Lin, Y Cui, F Zhao, et al., BZ Qian, Y Zhao#, Z Yuan#.

    Complete spatially resolved gene expression is not necessary for identifying spatial domains.

    Cell Genomics (2024).


    [8] Z Yuan*# & J Yao#.

    Harnessing Computational Spatial Omics to Explore the Spatial Biology Intricacies.

    Seminars in Cancer Biology (2023).


    [9] T Guo*, Z Yuan*, Y Pan, J Wang, F Chen, MQ Zhang#, X Li#.

    SPIRAL: integrating and aligning spatially resolved transcriptomics data across different experiments, conditions, and technologies.

    Genome Biology 24, 241 (2023).