Direction I: Molecular mechanisms and neural circuits in cognitive functions

· Investigate the structural and functional mechanisms of synaptic maturation, plasticity and connectivity underlying specific cognitive processes

· Characterize the molecular signaling pathways and pharmacological intervention sites in certain neurological and mental health disorders

· Detect synaptic projections with dynamic neuroimaging to determine the inter-relationship between brain regions in physiological and pathological models

· Decode the activity patterns of neuronal clusters to explain the principles of cognitive processing

Direction II: Computational modeling for cognitive processing

· Develop biophysical models of neuronal interactions to study the multi-scale coupling processes in advanced cognitive functions

· Estimate parametric models of hyperscale neural networks to determine the real-time dynamic properties underlying certain cognitive activities

· Combine multimodal brain data and computational neural networks to simulate parts of cognitive processing

· Establish the relationships among the neurodynamic behavior characteristics in neurological and psychiatric disorders

Direction III:Cognitive neuroscience in neurological and psychiatric disorders

· Establish a large-scale database of disease cohort and biological sample for neurological and psychiatric disorders

· Screen early diagnostic markers from pathophysiological imaging forachieve accurate diagnosis of brain diseases

· Conduct biochemical and biophysical neuromodulation in neural circuits related to the cognitive function to provide new approaches for the treatment of disorders.