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Research

  • Xiao Xiao
  • Research Direction：Neural Circuits and molecular mechanisms underlying emotional and cognitive disorders
  • Email：xiaoxiao@fudan.edu.cn
  • Website：https://www.researchgate.net/profile/Xiao-Xiao-90
  • Brief Introduction：Dr. Xiao Xiao is an Associate Professor/Principle Investigator at Fudan University, Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI). After receiving a B.S. in Biological Engineering at Xi’an Jiaotong University, Dr. Xiao performed her Ph.D. studies with Dr. Yuqiu Zhang and Dr. Zhiqi Zhao at Fudan University, Institute of Neurobiology. Dr. Xiao’s thesis work focused on the circuitry and molecular mechanisms that mediate aversive behavior to pain, which was supported by the Excellent Doctor Project Foundation of the Ministry of Education in China. She went on to do a postdoc fellowship with Dr. Anthony Koleske and Dr. Michael Higley at Yale University School of Medicine, where she identified molecular pathology of synapse stabilization and neural circuit plasticity. Dr. Xiao is the recipient of numerous awards including the Glaxo Smith Kline (GSK) Tomorrow’s Star Award, American Heart Association Postdoc Fellowship, Rising-Star Project, etc. By combining cognitive behavioral testing, an array of electrophysiological and optical methods in brain slices and in vivo, and machine-learning analysis, she is interested in exploring neural circuit and molecular mechanism of emotional and cognitive disorders.
  • Achievement：

    1.Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients.Huichun Luo, Yongzhi Huang, Alexander L. Green, Tipu Z. Aziz,Xiao Xiao,Shouyan Wang#,NeuroImage: Clinical (2021). 32,102876.

    2.MonkeyPosekit: Automated Markerless 2D Pose Estimation of Monkey, Chuxi Li, Chi Yang, Yerong Li, Shufei Feng, Zhen Zhang, Shisheng Xiong (*),Xiao Xiao (*), IEEE-CAC, (2021), Accepted.(*Co-corresponding author)

    3.基于时移和片组注意力融合的双流行为识别网络.肖子凡,刘逸群,李楚溪,张力,王守岩,肖晓,计算机系统应用Computer Systems & Applications(2022)31(1):204−211

    4.The role of the anterior cingulate cortex in translationalpain research.

    Xiao Xiao (*),Ming Ding, Yuqiu Zhang (*), Neuroscience Bulletin (2021) 37(3), 405-422.(*Co-corresponding author)

    5.Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Kai-Kai Zang (*),Xiao Xiao (*), Li-Qiang Chen,Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, Yu-Qiu Zhang. Anesthesiology July 2020, Vol. 133, 165–184.(*Co-First author)

    6.Functional dynamics of thalamic local field potentials correlated with modulation of neuropathic pain. Huichun Luo, Yongzhi Huang,Xiao Xiao,Wenjing Dai, Yingnan Nie, Xinyi Geng, Yongzhi Huang, Alex Green, Tipu Aziz, Shouyan Wang, European Journal of Neuroscience. 2020;51:628–640

    7.Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Sara M. Katrancha, Amy Zhao, Amanda Jeng, Juliana Shaw, Minsheng Zhu, Christopher Pittenger, Charles Greer,Xiao Xiao (*), Anthony J. Koleske (*). Cell Reports. (2019) 26:2805-2817 6.(*Co-corresponding author)

    8.A new perspective on the anterior cingulate cortex and affective pain.Xiao Xiao, Yu-qiu Zhang. Neuroscience & Biobehavioral Reviews (2018) 90:200-211.

    9.Noonan syndrome-associated SHP2 dephosphorylates GluN2B to regulate NMDA receptor function. Aaron D. Levy (*),Xiao Xiao (*), Suma Priya Sudarsana Devi, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske. Cell Reports (2018) 24 (6):1523-1535.(*Co-First author)

    10.10.CNS neurons deposit Laminin α5 to stabilize synapses. Mitchell H. Omar, Maghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske*. Cell Reports (2017) 21(5): 1281-1292

    11.Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice.Xiao Xiao, Aaron D. Levy, Brian J. Rosenberg, Michael J. Higley, Anthony J. Koleske. Journal of Neuroscience (2016) 36 (25): 6778-6791

    12.SIP 30 Is Required for Neuropathic Pain-Evoked Aversion in Rats. Mei Han,Xiao Xiao,Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhang*. Journal of Neuroscience (2014) 34(2): 346-355

    13.Estrogen in the anterior cingulate cortex contributes to pain-related aversion.Xiao Xiao, Yan Zhang, Yan Yang, Zhi-Qi Zhao, Yu-Qiu Zhang. Cerebral Cortex (2012) 23(9): 2190-2203 doi: 10.1093/cercor/bhs201

    14.Estrogen facilitates spinal cord synaptic transmission via mambrane-bound estrogen receptors: implications for pain hypersensitivity. Yan Zhang,Xiao Xiao, Zhi-Qi Zhao, Yu-Qiu Zhang*.Journal of Biological Chemistry(2012) 287(40):33268-81

    15.一念放下，万般自在——我们能否训练自己去遗忘疼痛.肖晓,生理学报Acta Physiologica Sinica, June 25, 2011, 63(3): 293–295

    16.NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats.Ting-Ting Li(*), Wen-Hua Ren(*),Xiao Xiao(*), Long-Zhen Cheng, Xue-Han Zhang, Zhi-Qi Zhao, Yu-Qiu Zhang.Pain 146 (2009) 183–193.(*Co-first author)


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