Peter Brown, Academician-Institute of Science and Technology for Brain-inspired Intelligence

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Research

Peter Brown, Academician
Research Direction：Clinical neurology, Neural fluctuation, Neural decoding, Neuronal circuit
Email：peter.brown@bndu.ox.ac.uk
Website：https://www.mrcbndu.ox.ac.uk/people/prof-peter-brown

Brief Introduction：Peter Brown is an emeritus Professor of Experimental Neurology in the Nuffield Department of Clinical Neurosciences, University of Oxford, and the founding Director of the MRC Brain Network Dynamics Unit at the University of Oxford.Peter graduated in Medicine at the University of Cambridge. He was appointed a Professor of Neurology at University College London in 2004, and in 2006, he became Head of the Sobell Department of Motor Neuroscience and Movement Disorders at the Institute of Neurology, University College London. He moved to the Nuffield Department of Clinical Neurosciences at the University of Oxford as Professor of Experimental Neurology in 2010, and in 2015, became the first Director of the MRC BNDU. He retired in 2021. Peter began his research in disorders of movement in the early 1990s, when he was instrumental in classifying and determining the underlying pathophysiology of myoclonus, and the stiff person and startle syndromes. Subsequently, Peter developed an interest in the pathophysiology of Parkinson’s disease, establishing that synchronised oscillations amongst nerve cells in the basal ganglia of the brains of people with Parkinson’s are linked to symptoms of stiffness and slowness, and successfully pioneering therapeutic interventions that leverage this phenomenon.
Achievement：

1.Khawaldeh S Tinkhauser G Shah SA Petermann K Debove I Nguyen TAK Nowacki A Lachenmayer ML Schuepbach M Pollo C Krack P Woolrich M Brown P.Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease.2020. Brain, 143(2):582-596.

2.Torrecillos F Falato E Pogosyan A West TO Di Lazzaro V Brown P.Motor cortex inputs at the optimum phase of beta cortical oscillations undergo more rapid and less variable corticospinal propagation.2020. J. Neurosci., 40(2):369-381.

3.Herz DM Little S Pedrosa D Tinkhauser G Cheeran B Foltynie T Bogacz R Brown P.Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson's Disease.2018. Curr. Biol., 28(8):1169-1178.e6.

4.Tinkhauser G Pogosyan A Little S Beudel M Herz DM Tan H Brown P.The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease.2017. Brain, 140(4):1053-1067.

5.Cagnan H Pedrosa D Little S Pogosyan A Cheeran B Aziz TZ Green AL Fitzgerald J Foltynie T Limousin P Zrinzo L Hariz M Friston KJ Denison T Brown P.Stimulating at the right time: phase-specific deep brain stimulation.2017. Brain, 140(1):132-145.