Jingqi Chen-Institute of Science and Technology for Brain-inspired Intelligence

Home · People · Faculty · Associate Professors / Young Principal Investigators · Content

People

Jingqi Chen
Research Direction：understanding the roles of noncoding genome in neurological diseases
Email：jingqichen@fudan.edu.cn
Website：https://www.researchgate.net/profile/Jingqi_Chen

Brief Introduction：Dr Chen graduated from Fudan university with a Ph.D. in bioinformatics, and did her postdoctoral research in University of California, Berkeley. Dr Chen joined ISTBI Fudan in Janurary, 2019. Dr Chen mainly studies the roles of the noncoding genome in neurological and psychiatric diseases, through multi-omics data-driven approaches. In particular, current research goals include: (1) understanding the genetic roles and clinical impact of rare SNPs and SVs in Alzheimer's disease and Schizophrenia; (2) identifying and interpreting disease-relevant repeat elements/endogenous retrovirus in the context of brain disorders. Both goals are powered by big and diversed local and public data, and the design of biologically meaningful bioinformatics methods. Welcome to join our research! Please contact Dr Chen at jingqichen @ fudan.edu.cn if interested in PHD/postdoc positions.
Achievement：

1 An, Z., Jiang, A. & Chen, J.* Toward understanding the role of genomic repeat elements in neurodegenerative diseases. Neural Regen Res 20, 646-659, doi:10.4103/NRR.NRR-D-23-01568 (2025).
2 Cao, J., Zhang, C., Lo, C. Z., Guo, Q., Ding, J., Luo, X., Zhang, Z. C., Chen, F., Consortium, Z. I. B., Cheng, T. L.*, Chen, J.*, Zhao, X. M.* & for the Alzheimer's Disease Neuroimaging Initiative. Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease. Alzheimers Dement. 21(2):e14444. doi: 10.1002/alz.14444 (2024).
3 Yuan, B., Zhang, S., Song, L., Chen, J., Cao, J., Qiu, J., Qiu, Z., Chen, J.*, Zhao, X. M.* & Cheng, T. L.* Engineering of cytosine base editors with DNA damage minimization and editing scope diversification. Nucleic Acids Res 51, e105, doi:10.1093/nar/gkad855 (2023).
4 Chen, J.*, Song, L., Yang, A., Dong, G. & Zhao, X. M.* Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders. Mol Psychiatry 27, 2720-2730, doi:10.1038/s41380-022-01529-3 (2022).
5 Dong, G., Feng, J., Sun, F., Chen, J.* & Zhao, X. M.* A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank. Genome Med 13, 110, doi:10.1186/s13073-021-00927-6 (2021).